Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Org Lett. 2013 Sep 6;15(17):4552-5. doi: 10.1021/ol4021089. Epub 2013 Aug 19.
6-Hydroxy-3-oxo-3H-xanthene-9-carboxylic acid is introduced as the first transition-metal-free carbon monoxide releasing molecule activated by visible light (photoCORM). This water-soluble fluorescein analogue releases carbon monoxide in both water and methanol upon irradiation at 500 nm. When selectively irradiated in the presence of hemoglobin (Hb) under physiological conditions, released CO is quantitatively trapped to form carboxyhemoglobin (COHb). The reaction progress can be accurately monitored by characteristic absorption and emission properties of the reactants and products.
6- 羟基 -3- 氧代 -3H- 呫吨 -9- 羧酸被引入作为第一个可见光激活的无过渡金属一氧化碳释放分子（photoCORM）。这种水溶性荧光素类似物在 500nm 照射下，在水和甲醇中均可释放一氧化碳。在生理条件下，当血红蛋白（Hb）存在时选择性照射时，释放的 CO 被定量捕获形成碳氧血红蛋白（COHb）。反应进度可以通过反应物和产物的特征吸收和发射性质来准确监测。
