Dose-related accumulation of organophosphate phosphamidon in discrete regions of the CNS: correlation with its neurotoxicity.

Phosphamidon was detected by thin-layer chromatography (TLC) from various CNS regions of the rats intoxicated with three doses (1.0, 1.5 and 2.0 mg/kg body-weight) intraperitoneally daily for seven days. A distinct dose-related increase in its concentration was observed in all investigated areas of the CNS. Regions with higher gray matter composition showed greater uptake of phosphamidon compared to those rich in white matter. This is in accordance with our previous study (Naqvi et al. 1988) revealing similar pattern in the effect of phosphamidon on the phospholipids in the brain.