Behera B C, Bhunya S P
Toxicol Lett. 1987 Aug;37(3):269-77. doi: 10.1016/0378-4274(87)90142-1.
The genotoxic effect of phosphamidon in mice in an in vivo test system was investigated by 3 different assays: chromosomal aberration, micronucleus and sperm-shape abnormality. The chemical was administered to groups of mice via 3 routes (i.p., p.o. and s.c.), acutely in 3 dose regimens (5, 4 and 3 mg/kg) and subacutely or chronically (5 X 1 mg/kg). The animals were sacrificed at different times: after 6, 24, 48 and 120 h for chromosomal aberration, 30 h for micronucleus and 35 days for sperm-shape abnormality. Significant effects were observed in all assays. Chronic exposure to fractionated doses induced less effect than the equivalent acute dose. The results were dose- as well as time-responsive and indicated the genetic peril of phosphamidon in the present, in vivo system.
通过三种不同的试验（染色体畸变、微核和精子形态异常试验），在体内试验系统中研究了磷胺对小鼠的遗传毒性作用。该化学物质通过三种途径（腹腔注射、口服和皮下注射）给予小鼠组，急性给予三种剂量方案（5、4和3 mg/kg）以及亚急性或慢性给予（5×1 mg/kg）。在不同时间处死动物：染色体畸变试验在6、24、48和120小时后，微核试验在30小时后，精子形态异常试验在35天后。在所有试验中均观察到显著影响。与等效急性剂量相比，慢性分次给药诱导的影响较小。结果具有剂量和时间依赖性，表明在本体内系统中磷胺具有遗传危险性。
