Törnros J, Laurell H
National Swedish Road and Traffic Research Institute (VTI), Linköping, Sweden.
Pharmacol Toxicol. 1990 Jul;67(1):77-80. doi: 10.1111/j.1600-0773.1990.tb00786.x.
Eighteen healthy volunteers of both sexes, aged 20-35 years, were tested in the morning after three nights of medication with brotizolam 0.25 mg, nitrazepam 5 mg or placebo on a monotonous simulated driving task. The effect measures were subsidiary auditory reaction time and time outside road. Measurements of self-rated alertness were carried out as well. No effects were demonstrated from treatments on either measure. Nitrazepam however tended to score worst on all measures, except time outside road which could not be analysed with respect to statistical significance because of an insufficient number of subjects leaving the road. Twelve of the subjects were also tested immediately after drug intake on the first night of each medication period. Reaction time decrement was observed in both active drugs conditions with no difference between the two. The other measures, however non-significant, pointed in the same direction with the greatest decrement for nitrazepam.
18名年龄在20至35岁之间的健康男女志愿者，在连续三晚服用0.25毫克溴替唑仑、5毫克硝西泮或安慰剂后，于早晨接受了一项单调模拟驾驶任务测试。效果指标为辅助听觉反应时间和偏离道路时间。同时也进行了自我评定警觉性测量。各治疗组在任何一项指标上均未显示出效果。然而，硝西泮在所有指标上的得分往往最差，不过由于离开道路的受试者数量不足，无法对偏离道路时间进行统计学意义上的分析。在每个用药期的第一晚，12名受试者在服药后也立即接受了测试。在两种活性药物条件下均观察到反应时间缩短，且两者之间无差异。然而，其他指标虽无统计学意义，但指向相同方向，硝西泮导致的下降幅度最大。
