在印度北部居住的印度裔人群中，低 25 羟维生素 D 和高甲状旁腺激素水平与非酒精性脂肪性肝病存在独立关联。
Independent associations of low 25 hydroxy vitamin D and high parathyroid hormonal levels with nonalcoholic fatty liver disease in Asian Indians residing in north India.
机构信息
Diabetic Foundation (India) and National Diabetes Obesity and Cholesterol Foundation, New Delhi, India.
出版信息
Atherosclerosis. 2013 Sep;230(1):157-63. doi: 10.1016/j.atherosclerosis.2013.07.006. Epub 2013 Jul 22.
OBJECTIVE
We analysed the associations of 25 hydroxy vitamin D [25(OH) D] and parathyroid hormone (PTH) levels with clinical, anthropometric, biochemical and body composition parameters in Asian Indians with nonalcoholic fatty liver disease (NAFLD).
METHODS
In this case-control study, 162 cases and 173 age and sex matched controls were recruited. Clinical, anthropometric, biochemical parameters and liver ultrasound were done. Percentage body fat (%BF), lean body mass and bone mineral density (BMD) were assessed by dual energy X-ray absorptiometry (DXA). Fasting insulin levels, value of homeostasis model assessment of insulin resistance (HOMA-IR), serum 25(OH) D, calcium and PTH levels were measured.
RESULTS
Subjects with NAFLD had lower serum 25(OH) D (19.4 ± 8.5 vs. 27.8 ± 9.4 ng/ml, p = 0.0001) and higher serum PTH (54.9 ± 19.5 vs.41.5 ± 18.3 pg/ml, p = 0.0001) levels as compared to controls. We observed significantly high values of systolic blood pressure (p = 0.002), waist circumference (p = 0.05), serum triglycerides (p = 0.002), total cholesterol (p = 0.002), alanine transaminase (p = 0.05), fasting insulin (p = 0.02) and HOMA-IR (p = 0.03) in the lowest 25(OH) D quartile. Multivariable-logistic regression showed that low serum 25(OH) D [OR (95%CI): 4.46 (2.58-7.72), p = 0.0001] and high PTH [OR (95%CI): 2.21 (1.50-3.30), p = 0.0001] level were independently associated with NAFLD.
CONCLUSION
Low serum 25(OH) D and high PTH levels were independently associated with the presence of NAFLD in Asian Indians residing in north India.
目的
我们分析了 25 羟维生素 D [25(OH)D]和甲状旁腺激素 (PTH)水平与非酒精性脂肪性肝病 (NAFLD) 印度裔人群的临床、人体测量学、生化和身体成分参数之间的关系。
方法
在这项病例对照研究中，共招募了 162 例病例和 173 例年龄和性别匹配的对照。进行了临床、人体测量学、生化参数和肝脏超声检查。通过双能 X 射线吸收法 (DXA) 评估体脂肪百分比 (%BF)、瘦体重和骨密度 (BMD)。测量空腹胰岛素水平、稳态模型评估的胰岛素抵抗 (HOMA-IR) 值、血清 25(OH)D、钙和 PTH 水平。
结果
与对照组相比，NAFLD 患者的血清 25(OH)D 水平较低（19.4 ± 8.5 vs. 27.8 ± 9.4ng/ml，p = 0.0001），血清 PTH 水平较高（54.9 ± 19.5 vs. 41.5 ± 18.3pg/ml，p = 0.0001）。我们观察到收缩压（p = 0.002）、腰围（p = 0.05）、血清甘油三酯（p = 0.002）、总胆固醇（p = 0.002）、丙氨酸转氨酶（p = 0.05）、空腹胰岛素（p = 0.02）和 HOMA-IR（p = 0.03）在血清 25(OH)D 最低四分位数的水平显著升高。多变量逻辑回归显示，血清 25(OH)D 水平低[比值比 (95%CI)：4.46(2.58-7.72)，p = 0.0001]和 PTH 水平高[比值比 (95%CI)：2.21(1.50-3.30)，p = 0.0001]与 NAFLD 独立相关。
结论
在印度北部居住的印度裔人群中，血清 25(OH)D 水平低和 PTH 水平高与 NAFLD 的存在独立相关。
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