Department of General Medicine, Chengdu Second People's Hospital, Chengdu, 610000, China.
Department of Geriatrics, Chengdu Second People's Hospital Chengdu, Chengdu, 610000, China.
Eur J Med Res. 2022 Aug 8;27(1):143. doi: 10.1186/s40001-022-00775-z.
We examined the association between nonalcoholic fatty liver disease and lumbar spine bone mineral density in individuals with and without type 2 diabetes.
The lumbar BMD of 1088 subjects was measured using dual-energy X-ray absorptiometry (DXA). Liver fat content was quantified via B-mode ultrasound. Multivariable linear regression was used to study the association between NAFLD and lumbar BMD in participants with and without T2DM.
The lumbar BMD in the T2DM group and the non-diabetes group was higher in the NAFLD group than in the non-NAFLD group (P < 0.001). Multivariate regression analysis in the T2DM group showed that after adjusting for confounders, the positive association between lumbar spine BMD and NAFLD remained (P = 0.027). In the non-diabetes group, after adjusting for confounders, the association between NAFLD and lumbar spine BMD disappeared.
The relationship between nonalcoholic fatty liver disease and lumbar bone mineral density may differ in individuals with and without diabetes. The effect of nonalcoholic fatty liver disease on bone mineral density needs to be evaluated in different clinical contexts.
研究 2 型糖尿病（T2DM）患者和非 2 型糖尿病患者中非酒精性脂肪性肝病（NAFLD）与腰椎骨密度之间的关系。
采用双能 X 射线吸收法（DXA）对 1088 例受试者的腰椎骨密度进行测量，采用 B 型超声对肝脏脂肪含量进行量化。采用多变量线性回归分析 T2DM 患者和非糖尿病患者中 NAFLD 与腰椎骨密度之间的关系。
T2DM 组和非糖尿病组中，NAFLD 组的腰椎骨密度均高于非 NAFLD 组（P<0.001）。在 T2DM 组中，经多变量回归分析校正混杂因素后，腰椎骨密度与 NAFLD 之间仍呈正相关（P=0.027）。在非糖尿病组中，校正混杂因素后，NAFLD 与腰椎骨密度之间的关联消失。
NAFLD 与腰椎骨密度之间的关系在糖尿病患者和非糖尿病患者中可能不同。在不同的临床环境中，需要评估非酒精性脂肪性肝病对骨密度的影响。
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