Kononenko V Ia, Kosmina N M, Pil'kevich L I
Probl Endokrinol (Mosk). 1990 May-Jun;36(3):49-53.
The effect of single (1.4 and 24 h) and long-term (7 days) hydrocortisone intramuscular administration (5 mg/100 g of body mass) on 5'-nucleotidase and adenosine deaminase activities in homogenate and subcellular fractions of the rat brain hypothalamus and hippocampus has been studied. Enzymatic activity of adenosine metabolism in hypothalamus and hippocampus has been shown to undergo changes with the duration of hydrocortisone administration. A possible role of adenosine in the mechanism of glucocorticoid action in the CNS and the regulation of the hypothalamic-pituitary-adrenal axis is under discussion.
研究了单次（1.4小时和24小时）和长期（7天）肌肉注射氢化可的松（5毫克/100克体重）对大鼠脑下丘脑和海马匀浆及亚细胞组分中5'-核苷酸酶和腺苷脱氨酶活性的影响。结果表明，下丘脑和海马中腺苷代谢的酶活性随氢化可的松给药时间的延长而发生变化。文中还讨论了腺苷在中枢神经系统糖皮质激素作用机制及下丘脑-垂体-肾上腺轴调节中的可能作用。
