Ito Kimiteru, Nakata Yasuhiro, Matsuda Hiroshi, Sugai Kenji, Watanabe Masako, Kamiya Kouhei, Kimura Yukio, Shigemoto Yoko, Okazaki Mitsutoshi, Sasaki Masayuki, Sato Noriko
Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Brain Dev. 2014 Aug;36(7):578-84. doi: 10.1016/j.braindev.2013.07.017. Epub 2013 Aug 16.
The purpose of this retrospective study was to clarify the cellular activities of ectopic neurons in subcortical bands and to evaluate the imaging features of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and (99m)Tc ethyl cysteinate dimer (ECD) single-photon emission computed tomography (SPECT) in a series of patients with subcortical band heterotopia (SBH).
The cases of 12 patients with SBH (3 men and 9 women; age range, 2-51 years) were evaluated on the basis of their MRI findings. Eight (18)F-FDG PET and 12 (99m)Tc-ECD SPECT images were obtained. The uptakes of these images were compared with electroencephalography (EEG) or MRI findings such as band thickness. In all patients, easy Z-score Imaging System (eZIS) software was used to statistically analyze the SPECT images.
Of the eight (18)F-FDG PET images, five showed higher uptake in the thick subcortical bands than in the overlying cortex. Of the 12 (99m)Tc-ECD SPECT examinations with eZIS images, nine indicated increased regional cerebral blood flow (rCBF) areas corresponding to the band locations. Of the eight (18)F-FDG PET examination findings, six were congruent with the rCBF distributions on the eZIS images. Eight of the 12 patients showed correspondence to the increased rCBF on the eZIS images, the band locations on MRI, and abnormal discharge sites on EEG.
Ectopic neurons in subcortical bands may have higher glucose metabolism and/or increased rCBF compared to the overlying cortex. (18)F-FDG PET and (99m)Tc-ECD SPECT using eZIS can be helpful to clearly detect the cellular activities of ectopic neurons in patients with SBH.
本回顾性研究的目的是阐明皮质下带异位神经元的细胞活性，并评估一系列皮质下带异位症（SBH）患者的氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）和锝[99mTc]乙胱氨酸二聚体（ECD）单光子发射计算机断层扫描（SPECT）的成像特征。
根据MRI表现对12例SBH患者（3例男性，9例女性；年龄范围2至51岁）进行评估。获取了8例氟代脱氧葡萄糖（18F-FDG）PET和12例锝[99mTc]乙胱氨酸二聚体（99mTc-ECD）SPECT图像。将这些图像的摄取情况与脑电图（EEG）或MRI表现（如带厚度）进行比较。所有患者均使用简易Z评分成像系统（eZIS）软件对SPECT图像进行统计分析。
在8例氟代脱氧葡萄糖（18F-FDG）PET图像中，5例显示厚皮质下带的摄取高于其上覆皮质。在12例使用eZIS图像的锝[99mTc]乙胱氨酸二聚体（99mTc-ECD）SPECT检查中，9例显示对应带位置的局部脑血流量（rCBF）增加区域。在8例氟代脱氧葡萄糖（18F-FDG）PET检查结果中，6例与eZIS图像上的rCBF分布一致。12例患者中有8例显示与eZIS图像上增加的rCBF、MRI上的带位置以及EEG上的异常放电部位相对应。
与上覆皮质相比，皮质下带的异位神经元可能具有更高的葡萄糖代谢和/或增加的rCBF。使用eZIS的氟代脱氧葡萄糖（18F-FDG）PET和锝[99mTc]乙胱氨酸二聚体（99mTc-ECD）SPECT有助于清晰检测SBH患者异位神经元的细胞活性。
