CATP 是 Neurospora 生物钟的关键组成部分，通过调节频率基因座处核小体的占有率节律。
CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus.
机构信息
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
出版信息
EMBO Rep. 2013 Oct;14(10):923-30. doi: 10.1038/embor.2013.131. Epub 2013 Aug 20.
Abstract
Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.
摘要
节律性 frq 转录对于 Neurospora 生物钟的功能至关重要。在这里，我们表明 frq 启动子处存在生物钟组蛋白占据节律，该节律受 FREQUENCY (FRQ) 调控。通过正向遗传学和基因组测序的组合，我们鉴定出 Clock ATPase (CATP) 是一个必需的生物钟组成部分。我们的结果表明，CATP 与 frq 基因座和其他 WCC 靶基因结合，并促进这些基因座上组蛋白的去除，从而允许生物钟基因的转录。这些结果表明，生物钟基因上组蛋白占据节律的节律性控制对于生物钟功能至关重要。
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