State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Chem Commun (Camb). 2013 Oct 9;49(78):8788-90. doi: 10.1039/c3cc43290d.
Ferric ions show high affinity to the kinase-generated phosphorylated sites of peptides. Thus, the high electrocatalytic activity of the coordinated ferric ions toward the reduction of hydrogen peroxide can be used for sensitive label-free monitoring of protein kinase activity and inhibition.
三价铁离子对肽段中激酶生成的磷酸化位点具有高亲和力。因此，配位的三价铁离子对过氧化氢还原的高电催化活性可用于灵敏的无标记监测蛋白激酶活性和抑制。
