HippDB：一个易于靶向的螺旋蛋白-蛋白相互作用数据库。
HippDB: a database of readily targeted helical protein-protein interactions.
机构信息
Department of Anthropology and Department of Chemistry, New York University, New York, NY 10003, USA.
出版信息
Bioinformatics. 2013 Nov 1;29(21):2806-7. doi: 10.1093/bioinformatics/btt483. Epub 2013 Aug 19.
Abstract
SUMMARY
HippDB catalogs every protein-protein interaction whose structure is available in the Protein Data Bank and which exhibits one or more helices at the interface. The Web site accepts queries on variables such as helix length and sequence, and it provides computational alanine scanning and change in solvent-accessible surface area values for every interfacial residue. HippDB is intended to serve as a starting point for structure-based small molecule and peptidomimetic drug development.
AVAILABILITY AND IMPLEMENTATION
HippDB is freely available on the web at http://www.nyu.edu/projects/arora/hippdb. The Web site is implemented in PHP, MySQL and Apache. Source code freely available for download at http://code.google.com/p/helidb, implemented in Perl and supported on Linux.
CONTACT
摘要
摘要
HippDB 对蛋白质数据库中具有一个或多个界面螺旋的每一个结构可及的蛋白-蛋白相互作用进行编目。该网站接受关于变量（如螺旋长度和序列）的查询，并为每个界面残基提供计算丙氨酸扫描和溶剂可及表面积值的变化。HippDB 旨在作为基于结构的小分子和肽模拟药物开发的起点。
可用性和实现
HippDB 可在 http://www.nyu.edu/projects/arora/hippdb 上免费获得。该网站是用 PHP、MySQL 和 Apache 实现的。源代码可在 http://code.google.com/p/helidb 免费下载，用 Perl 编写，支持 Linux。
联系人
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