Acta Neurochir (Wien). 2013 Nov;155(11):2037-43. doi: 10.1007/s00701-013-1841-7.
We aimed to assess the prevalence of unruptured intracranial aneurysms (UIAs) in healthy asymptomatic adults, and investigate the differences in incidence due to gender and age in Japan.
Magnetic resonance angiography (MRA) results of healthy asymptomatic adults who underwent the procedure for examination of the brain, from April 2010 to March 2012, were retrospectively examined. Patients with a history of ruptured aneurysm and UIAs were excluded. UIAs greater than 2.0 mm in size were counted. In accordance with these criteria, 8,696 people with a mean age of 52.2±9.5 years were examined, and 37.4 % of these individuals were women.
The overall prevalence of UIAs was 3.2 %. The prevalence in women was higher than that in men (4.4 % versus 2.5 %, OR, 1.81; 95% CI, 1.4 to 2.31). The prevalence increased with age in both genders. In under 49 years, the prevalence in women and men were 2.7 % and 1.9 %, respectively, with no significant differences (OR, 1.47; CI, 0.91 to 2.37). In over 50 years, the prevalence in women was higher than that in men (5.4 % versus 2.8 %, OR, 2.01; CI, 1.52–2.67). There were significant differences in the locations of UIAs by gender (P <0.001); Internal carotid artery was more frequent in women, whereas anterior cerebral artery and middle cerebral artery were more common inmen.
This study provides etiological data on the prevalence of UIAs in healthy asymptomatic Japanese adults, and may be useful in determining therapeutic managements for UIAs.
本研究旨在评估日本健康无症状成年人中未破裂颅内动脉瘤（UIAs）的患病率，并探讨性别和年龄对其发病率的影响差异。
回顾性分析了 2010 年 4 月至 2012 年 3 月期间因脑检查而接受磁共振血管造影（MRA）检查的健康无症状成年人的 MRA 结果。排除有破裂性动脉瘤和 UIAs 病史的患者。计算大于 2.0mm 的 UIAs 数量。根据这些标准，共检查了 8696 名平均年龄为 52.2±9.5 岁的个体，其中 37.4%为女性。
UIAs 的总体患病率为 3.2%。女性的患病率高于男性（4.4%比 2.5%，OR，1.81；95%CI，1.4 至 2.31）。两性的患病率均随年龄增长而增加。在 49 岁以下，女性和男性的患病率分别为 2.7%和 1.9%，差异无统计学意义（OR，1.47；95%CI，0.91 至 2.37）。在 50 岁以上，女性的患病率高于男性（5.4%比 2.8%，OR，2.01；95%CI，1.52-2.67）。UIAs 的位置在两性之间存在显著差异（P<0.001）；女性中颈内动脉更为常见，而男性中前交通动脉和大脑中动脉更为常见。
本研究为日本健康无症状成年人 UIAs 的患病率提供了病因学数据，可能有助于确定 UIAs 的治疗管理策略。
