Galassi Waneerat, Yuyangkate Warin, Paholthep Paweena, Tangsriwong Thipsumon, Jaikon Ponnarong, Leiwan Thongchai, Jiranukool Jiroje, Thiarawat Peeraphong
Department of Radiology, Naresuan University, Tha Pho, Thailand.
Department of Surgery Buddhashinnaraj Hospital, Mueang, Phitsanulok, Thailand.
Surg Neurol Int. 2021 Nov 23;12:566. doi: 10.25259/SNI_741_2021. eCollection 2021.
The prevalence of familial unruptured intracranial aneurysm (UIA) in Thai population was unknown.
Our study population comprised first-degree relatives of patients who were diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) in two cerebrovascular neurosurgical centers from January 2018 to December 2018. The volunteers underwent three-dimensional time-of-flight magnetic resonance angiography for screening intracranial aneurysms (IA). Those who were reported positive or suspected of IA then underwent computed tomography angiography for confirmation.
We identified 12 patients who had 12 unruptured IAs (UIAs) from among 93 first-degree relatives. The prevalence of UIA among our study population was 12.9%. An estimated prevalence of UIA among Thai population was 9.05% (95% confidence interval [CI] 7.32-10.78). Of the 93 relatives, 84 had only one first-degree relative who suffered aSAH. Siblings posed a higher risk for UIA than offspring (16% vs. 9.5%), but the difference was not statistically significant (odds ratio 1.810, 95% CI 0.50-6.50, = 0.274). The most common aneurysm location was the anterior cerebral artery territory (50%).
The prevalence of familial UIA in a Thai population was relatively high. There was no significant between-group difference in the occurrence of UIA between the siblings and offspring of the aSAH patients.
泰国人群中家族性未破裂颅内动脉瘤（UIA）的患病率尚不清楚。
我们的研究人群包括2018年1月至2018年12月期间在两个脑血管神经外科中心被诊断为动脉瘤性蛛网膜下腔出血（aSAH）患者的一级亲属。志愿者接受三维时间飞跃磁共振血管造影以筛查颅内动脉瘤（IA）。那些被报告为IA阳性或疑似IA的患者随后接受计算机断层血管造影以进行确诊。
我们在93名一级亲属中识别出12例患有12个未破裂IA（UIA）的患者。我们研究人群中UIA的患病率为12.9%。泰国人群中UIA的估计患病率为9.05%（95%置信区间[CI]7.32 - 10.78）。在这93名亲属中，84人只有一名患有aSAH的一级亲属。兄弟姐妹患UIA的风险高于后代（16%对9.5%），但差异无统计学意义（优势比1.810，95%CI 0.50 - 6.50，P = 0.274）。最常见的动脉瘤位置是大脑前动脉区域（50%）。
泰国人群中家族性UIA的患病率相对较高。aSAH患者的兄弟姐妹和后代之间UIA的发生在组间无显著差异。
