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Targeting RV failure and cardiomyocyte injury in acute pulmonary thromboembolism.

作者信息

Tanus-Santos Jose E

机构信息

Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Avenida dos Bandeirantes, 3900, 14049-900 Ribeirao Preto, Sao Paulo, Brazil

出版信息

Nat Rev Cardiol. 2013 Oct;10(10):559. doi: 10.1038/nrcardio.2013.12-c1. Epub 2013 Aug 20.

DOI:10.1038/nrcardio.2013.12-c1
PMID:23959228
Abstract
摘要

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Doxycycline prevents acute pulmonary embolism-induced mortality and right ventricular deformation in rats.强力霉素可预防大鼠急性肺栓塞诱导的死亡率和右心室变形。
Cardiovasc Drugs Ther. 2013 Aug;27(4):259-67. doi: 10.1007/s10557-013-6458-9.
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Assessment and treatment of right ventricular failure.右心衰竭的评估和治疗。
Nat Rev Cardiol. 2013 Apr;10(4):204-18. doi: 10.1038/nrcardio.2013.12. Epub 2013 Feb 12.
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Matrix metalloproteinases as drug targets in acute pulmonary embolism.基质金属蛋白酶作为急性肺栓塞的药物靶点。
Curr Drug Targets. 2013 Mar;14(3):344-52. doi: 10.2174/1389450111314030006.
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Antioxidant treatment protects against matrix metalloproteinase activation and cardiomyocyte injury during acute pulmonary thromboembolism.抗氧化治疗可预防急性肺血栓栓塞症时基质金属蛋白酶的激活和心肌细胞损伤。
Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):685-96. doi: 10.1007/s00210-012-0748-9. Epub 2012 May 3.
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Myocardial pathology in pulmonary thromboembolism.肺血栓栓塞症的心肌病理学。
Heart. 2011 Oct;97(20):1695-9. doi: 10.1136/hrt.2011.226209. Epub 2011 Jul 26.
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Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism.金属蛋白酶抑制可预防实验性急性肺血栓栓塞症中心肌细胞损伤。
Crit Care Med. 2011 Feb;39(2):349-56. doi: 10.1097/CCM.0b013e3181fa3dfe.
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Clin Chim Acta. 2008 Feb;388(1-2):184-8. doi: 10.1016/j.cca.2007.11.001. Epub 2007 Nov 12.
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Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9.阿托伐他汀对大鼠急性肺栓塞模型的保护作用：基质金属蛋白酶-9的参与
Crit Care Med. 2007 Jan;35(1):239-45. doi: 10.1097/01.CCM.0000251638.67104.C3.
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A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism.基质金属蛋白酶-9在急性肺栓塞后血流动力学变化中的作用。
Int J Cardiol. 2007 Jan 2;114(1):22-7. doi: 10.1016/j.ijcard.2005.11.109. Epub 2006 May 2.
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l-Arginine attenuates acute pulmonary embolism-induced oxidative stress and pulmonary hypertension.左旋精氨酸减轻急性肺栓塞诱导的氧化应激和肺动脉高压。
Nitric Oxide. 2005 Feb;12(1):9-14. doi: 10.1016/j.niox.2004.10.009. Epub 2004 Dec 23.