Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile; Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA.
Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile.
Autophagy. 2013 Oct;9(10):1455-66. doi: 10.4161/auto.25969. Epub 2013 Aug 14.
Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been implicated in the pathogenesis of a wide range of heart pathologies. However, the precise role of autophagy in these contexts remains obscure owing to its multifarious actions. Here, we review recently derived insights regarding the role of autophagy in multiple manifestations of cardiac plasticity and disease.
尽管最近在科学和技术上取得了进步，但心血管疾病仍然是全球发病率和死亡率的主要原因。自噬是细胞应对应激的一种古老的进化反应，它与多种心脏病理的发病机制有关。然而，由于自噬的多种作用，其在这些情况下的确切作用仍然不清楚。在这里，我们回顾了最近关于自噬在心脏可塑性和疾病的多种表现中的作用的研究进展。
