Butera P C, Beikirch R J, Willard D M
Department of Psychology, Niagara University, NY 14109.
Physiol Behav. 1990 Jun;47(6):1291-3. doi: 10.1016/0031-9384(90)90386-i.
The present experiment was conducted to determine if central implants of 17 alpha-estradiol could influence food intake, water intake, and body weight in ovariectomized rats. A total of fifteen animals were fitted with bilateral guide cannulae in the paraventricular nucleus (PVN) and stimulated unilaterally with cholesterol and 17 alpha-estradiol in each side of the brain. Compared with cholesterol treatment, 17 alpha-estradiol implants in the PVN significantly lowered food intake and body weight but did not affect water intake. These findings indicate that the PVN is a brain region responsive to the effects of 17 alpha-estradiol on feeding behavior, and support the hypothesis that the effects of estrogens on ingestive and reproductive behaviors are organized separately within the brain.
本实验旨在确定在去卵巢大鼠脑室内植入17α-雌二醇是否会影响其食物摄入量、饮水量和体重。总共15只动物在室旁核（PVN）植入双侧引导套管，并在脑的每一侧分别用胆固醇和17α-雌二醇进行单侧刺激。与胆固醇处理相比，在PVN植入17α-雌二醇可显著降低食物摄入量和体重，但不影响饮水量。这些发现表明，PVN是一个对17α-雌二醇影响摄食行为有反应的脑区，并支持雌激素对摄食和生殖行为的影响在脑内是分别组织的这一假说。
