Donohoe T P, Stevens R
Pharmacol Biochem Behav. 1982 Jan;16(1):93-9. doi: 10.1016/0091-3057(82)90019-3.
ovariectomised rats were implanted unilaterally with cannulae aimed at the ventromedial nucleus-arcuate region of the hypothalamus. Crystalline implants of estradiol benzoate and of the antiestrogenic compound CI-628 over a 72-hour stimulation period caused significantly greater food intake reductions than did implants of cholesterol. More dorsal and lateral placements were generally ineffective in reducing food intake. Implants of estrone and estriol produced equivalent reductions in food intake and body weight to those produced by estradiol benzoate. The possible molecular mode of action is discussed.
将去卵巢大鼠单侧植入套管，使其指向下丘脑腹内侧核-弓状区域。在72小时的刺激期内，苯甲酸雌二醇和抗雌激素化合物CI-628的晶体植入物比胆固醇植入物导致的食物摄入量减少显著更多。更靠背侧和外侧的植入位置通常在减少食物摄入量方面无效。雌酮和雌三醇的植入物在减少食物摄入量和体重方面产生的效果与苯甲酸雌二醇产生的效果相当。文中讨论了可能的分子作用模式。
