生殖内分泌学：母体胆汁淤积与后代代谢异常。
Reproductive endocrinology: maternal cholestasis and offspring metabolic abnormalities.
机构信息
David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA.
出版信息
Nat Rev Endocrinol. 2013 Oct;9(10):567-8. doi: 10.1038/nrendo.2013.165. Epub 2013 Aug 20.
Abstract
Papacleovoulou and colleagues demonstrate that maternal cholestasis during pregnancy is associated with offspring adiposity and metabolic abnormalities, both in humans and in mice. This study reinforces the overwhelming evidence of the critical role of the in utero environment as a major determinant of adult health and disease.
摘要
帕帕克莱奥武娄及其同事的研究表明，妊娠期间的母体胆汁淤积与后代的肥胖和代谢异常有关，这在人类和小鼠中均有体现。这项研究进一步证实了子宫内环境作为成年健康和疾病主要决定因素的关键作用的压倒性证据。
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本文引用的文献
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The role of maternal-fetal cholesterol transport in early fetal life: current insights.母胎胆固醇转运在早期胎儿生命中的作用：最新见解。
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Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis.熊去氧胆酸治疗妊娠肝内胆汁淤积症的疗效：Meta 分析。
Gastroenterology. 2012 Dec;143(6):1492-501. doi: 10.1053/j.gastro.2012.08.004. Epub 2012 Aug 11.
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