以真性红细胞增多症为表现的脑动静脉畸形：一例报告及文献复习
Cerebral arteriovenous malformation presenting with polycythemia vera: A case report and literature review.
作者信息
Sami Mairaj T, Bohnstedt Bradley N, Hattab Eyas M, Markham Raymond, Cohen-Gadol Aaron A
机构信息
Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Int J Surg Case Rep. 2013;4(10):813-7. doi: 10.1016/j.ijscr.2013.06.019. Epub 2013 Jul 20.
INTRODUCTION
Cerebral arteriovenous malformations (AVM) usually present with headache, hemorrhage, or seizure. Erythropoietin (EPO) has demonstrated protective effects against ischemia within the CNS.
PRESENTATION OF CASE
The authors report a patient with a cerebral AVM and concurrent polycythemia associated with elevated serum EPO. Systemic EPO levels declined acutely after resection of the patient's AVM, and the polycythemia resolved in the following months.
DISCUSSION
Polycythemia secondary to a cerebral AVM, in the absence of extra-cerebral vascular lesions, has not been described in the literature.
CONCLUSION
The authors explore the mechanisms by which this patient's cerebral AVM could have induced EPO production within the brain, manifesting as polycythemia.
引言
脑动静脉畸形（AVM）通常表现为头痛、出血或癫痫发作。促红细胞生成素（EPO）已被证明对中枢神经系统缺血具有保护作用。
病例介绍
作者报告了一名患有脑AVM并伴有与血清EPO升高相关的红细胞增多症的患者。患者的AVM切除后，全身EPO水平急剧下降，红细胞增多症在接下来的几个月内得到缓解。
讨论
在无脑外血管病变的情况下，继发于脑AVM的红细胞增多症在文献中尚未见报道。
结论
作者探讨了该患者的脑AVM诱发脑内EPO生成并表现为红细胞增多症的机制。
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