Guo Shibing, Bai Rui, Zhao Wei, Wang Yuxin, Zhao Zhenqun, Feng Wei
Tumour Biol. 2014 Jan;35(1):469-73. doi: 10.1007/s13277-013-1065-8.
Cytovillin plays structural and regulatory roles in the assembly and stabilization of specialized plasma membrane domains and in the tumor angiogenesis. Cytovillin expression has been proposed to be an effective biomarker of prognosis in patients with osteosarcoma, and many studies have been performed to assess the prognostic role of cytovillin expression in patients with osteosarcoma. We performed this meta-analysis to provide a comprehensive evaluation of the role of cytovillin expression on the overall survival rate by calculating the pooled risk ratio (RR) with corresponding 95% confidence interval (95% CI). Finally, eight studies with a total of 415 patients with osteosarcoma were included into the meta-analysis. Meta-analysis of total eight studies showed that cytovillin expression was obviously associated with lower overall survival rate in patients with osteosarcoma (RR = 0.41, 95% CI 0.28–0.58, P < 0.001). Meta-analysis of five studies with large sample still showed that cytovillin expression was obviously associated with lower overall survival rate (RR = 0.48, 95% CI 0.38–0.60, P < 0.001). In conclusion, the meta-analysis shows that cytovillin expression is obviously associated with lower overall survival rate in patients with osteosarcoma, and it is an effective biomarker of prognosis.
细胞绒毛蛋白在特殊质膜结构域的组装与稳定以及肿瘤血管生成过程中发挥着结构和调节作用。细胞绒毛蛋白的表达已被认为是骨肉瘤患者预后的有效生物标志物，并且已经开展了许多研究来评估细胞绒毛蛋白表达在骨肉瘤患者中的预后作用。我们进行这项荟萃分析，通过计算合并风险比（RR）及相应的95%置信区间（95%CI），对细胞绒毛蛋白表达在总生存率方面的作用进行全面评估。最终，共有八项研究、总计415例骨肉瘤患者被纳入荟萃分析。对这八项研究的荟萃分析表明，细胞绒毛蛋白表达与骨肉瘤患者较低的总生存率显著相关（RR = 0.41，95%CI 0.28 - 0.58，P < 0.001）。对五项大样本研究的荟萃分析仍显示，细胞绒毛蛋白表达与较低的总生存率显著相关（RR = 0.48，95%CI 0.38 - 0.60，P < 0.001）。总之，荟萃分析表明，细胞绒毛蛋白表达与骨肉瘤患者较低的总生存率显著相关，且它是一种有效的预后生物标志物。
