嗅轴突中气味受体mRNA的存在及局部翻译情况的研究

Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons.

作者信息

Dubacq Caroline, Fouquet Coralie, Trembleau Alain

机构信息

Université Pierre et Marie Curie Paris 06 (UPMC), Unité Mixte de Recherche (UMR) 7102, Team Development and Plasticity of Neural Network, UMR 7102, F-75005, Paris, France; Centre National de la Recherche Scientifique, UMR 7102, F-75005, Paris, France.

出版信息

Dev Neurobiol. 2014 Mar;74(3):259-68. doi: 10.1002/dneu.22122. Epub 2013 Oct 7.

DOI:10.1002/dneu.22122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4879812/

Abstract

Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections.

摘要

啮齿动物的基因组中包含1000多个功能性气味受体基因，这些基因由从嗅觉上皮投射到嗅球的嗅觉感觉神经元特异性表达。已获得嗅觉感觉神经元轴突中存在气味受体mRNA并进行局部翻译的有力证据，但这些轴突mRNA的功能尚未明确。这篇综述的目的是讨论嗅觉感觉轴突中存在气味受体mRNA并进行局部翻译的证据，并推测它们在小鼠嗅觉感觉投射布线中的可能功能。

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