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小鼠嗅觉系统中的神经图谱形成。

Neural map formation in the mouse olfactory system.

机构信息

Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.

出版信息

Neuron. 2010 Aug 26;67(4):530-42. doi: 10.1016/j.neuron.2010.07.003.

Abstract

Odor signals received by odorant receptors (ORs) in the olfactory epithelium are represented as an odor map of activated glomeruli in the olfactory bulb. In the mouse olfactory system, it appears that much of axon pathfinding and sorting occurs autonomously by olfactory neuron axons. Here, we review the recent progress on the study of olfactory map formation in rodents. We will discuss how neuronal identity is represented at axon termini and how the OR-instructed axonal projection is regulated.

摘要

气味受体(OR)在嗅上皮中接收到的气味信号被表示为嗅球中激活的神经球的气味图谱。在小鼠嗅觉系统中,嗅神经元轴突似乎很大程度上自主地进行轴突寻路和分拣。在这里,我们综述了啮齿动物嗅觉图谱形成研究的最新进展。我们将讨论神经元身份如何在轴突末端表示,以及 OR 指导的轴突投射如何受到调节。

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