J Cardiovasc Transl Res. 2013 Dec;6(6):981-8. doi: 10.1007/s12265-013-9506-8.
Since contradictory findings have been reported on potential effects of statins in modulating the inflammatory response, we have analysed the biological activity of lovastatin both in vitro using the Raw 264.7 murine macrophagic cell line and in vivo using BALB/c mice. When added to Raw 264.7 cells in combination with lipopolysaccharide, lovastatin significantly potentiated the release of interleukin-1β, interleukin-6 and interleukin-12 with respect to lipopolysaccharide alone and showed an additive effect on the release of nitric oxide. Similarly, when lovastatin was intraperitoneally administrated to BALB/c mice, it did not induce any pro-inflammatory effect when used alone, but it significantly potentiated the pro-inflammatory activity of lipopolysaccharide, in terms of number of intraperitoneal cells and serum levels of serum amyloid A, interleukin-1β, interleukin-6 and interleukin-12. A potential clinical implication of our study is that lovastatin might exert a pro-inflammatory activity in subjects affected by inflammatory processes, with clinically evident or subclinical infections.
由于他汀类药物在调节炎症反应方面的潜在作用存在相互矛盾的研究结果，我们分析了洛伐他汀在体外使用 Raw 264.7 鼠巨噬细胞系和体内使用 BALB/c 小鼠中的生物学活性。当与脂多糖一起添加到 Raw 264.7 细胞中时，洛伐他汀与单独使用脂多糖相比，显著增强了白细胞介素-1β、白细胞介素-6 和白细胞介素-12 的释放，并对一氧化氮的释放具有相加作用。同样，当洛伐他汀腹膜内给予 BALB/c 小鼠时，单独使用时不会引起任何促炎作用，但它显著增强了脂多糖的促炎活性，表现在腹腔细胞数量和血清淀粉样蛋白 A、白细胞介素-1β、白细胞介素-6 和白细胞介素-12 的血清水平上。我们研究的一个潜在临床意义是，洛伐他汀可能在受炎症过程影响的患者中发挥促炎作用，这些患者存在临床明显或亚临床感染。
