Oliveira-Soares R, E Silva J Maia, Correia M Peres, André Marisa C
Dermatology Center, Hospital CUF Descobertas, Lisbon, Portugal.
Int J Trichology. 2013 Jan;5(1):22-5. doi: 10.4103/0974-7753.114709.
There is no consensus on the standard treatment options for female pattern androgenetic alopecia (AGA). Efficacy of finasteride in women is controversial. The purpose of this study was to evaluate the clinical efficacy and safety of 5 mg/day oral finasteride in normoandrogenic postmenopausal woman.
A total of 40 normoandrogenic postmenopausal women with AGA was enrolled in this study. They were treated with oral finasteride 5 mg/day for 18 months. Efficacy was evaluated by patient's satisfaction and global photograph assessment. All the 40 patients completed 18 months of finasteride treatment schedule.
After 6 months, 22 patients referred significant improvement, 12 moderate improvement, and 6 no improvement. Regarding to global photo assessment, 8 patients showed no improvement, 16 showed moderate improvement and 16 showed significant improvements at the 6(th) month. A slight improvement was observed over time from 6 to 12 and 18 months observation. Maintained libido reduction was referred by four patients and liver enzymes increase was observed in one patient. Older patients were more prone to worse response.
Finasteride 5 mg/day is effective and safe for the treatment of female AGA in postmenopausal women in the absence of clinical or laboratory signs of hyper-androgenism.
女性雄激素性脱发（AGA）的标准治疗方案尚无共识。非那雄胺对女性的疗效存在争议。本研究的目的是评估每日口服5毫克非那雄胺对雄激素水平正常的绝经后女性的临床疗效和安全性。
本研究共纳入40名雄激素水平正常的绝经后AGA女性患者。她们接受每日5毫克口服非那雄胺治疗18个月。通过患者满意度和整体照片评估来评价疗效。所有40名患者均完成了18个月的非那雄胺治疗疗程。
6个月后，22名患者表示有显著改善，12名患者有中度改善，6名患者无改善。关于整体照片评估，在第6个月时，8名患者无改善，16名患者有中度改善，16名患者有显著改善。从6个月到12个月及18个月的观察期内，随着时间推移观察到有轻微改善。4名患者提到性欲持续降低，1名患者观察到肝酶升高。年龄较大的患者更容易出现较差的反应。
在没有临床或实验室高雄激素血症迹象的情况下，每日5毫克非那雄胺对治疗绝经后女性的AGA有效且安全。
