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中度缺血性二尖瓣反流:是否有早期干预的必要?

Moderate ischemic mitral regurgitation: Is there a case for early intervention?

作者信息

Najm Hani K, Arifi Ahmed A, Omran Ahmed S, Ahmad Munir

机构信息

Section of Cardiac Surgery, Department of Cardiac Sciences, King Abdulaziz Cardiac Center, National Guard Health Affairs, Saudi Arabia.

出版信息

J Saudi Heart Assoc. 2010 Jul;22(3):115-9. doi: 10.1016/j.jsha.2010.04.011. Epub 2010 May 11.

DOI:10.1016/j.jsha.2010.04.011
PMID:23960603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3727541/
Abstract

Ischemic mitral regurgitation (IMR) results from left ventricular remodelling after myocardial infarction and severely affects cardiovascular mortality and morbidity. Ischemic mitral valve regurgitation also represents a negative prognostic factor for long-term survival in patients undergoing surgical myocardial revascularization. While severe mitral regurgitation should always be corrected during a coronary artery bypass operation, the decision making is more difficult in patients with a moderate degree of regurgitation. In this review, we wish to highlight the negative impact of IMR on long-term survival and discuss the available evidence for surgical correction of IMR at the time of coronary revascularization.

摘要

缺血性二尖瓣反流(IMR)是心肌梗死后左心室重构的结果,严重影响心血管疾病的死亡率和发病率。缺血性二尖瓣反流也是接受外科心肌血运重建患者长期生存的不良预后因素。虽然在冠状动脉搭桥手术中严重二尖瓣反流应始终予以纠正,但对于中度反流患者,决策更为困难。在本综述中,我们希望强调IMR对长期生存的负面影响,并讨论在冠状动脉血运重建时外科纠正IMR的现有证据。

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本文引用的文献

1
Predictors of improvement of unrepaired moderate ischemic mitral regurgitation in patients undergoing elective isolated coronary artery bypass graft surgery.接受择期单纯冠状动脉旁路移植术患者中未修复的中度缺血性二尖瓣反流改善的预测因素。
Circulation. 2009 Oct 13;120(15):1474-81. doi: 10.1161/CIRCULATIONAHA.108.842104. Epub 2009 Sep 28.
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Ring annuloplasty in chronic ischemic mitral regurgitation: encouraging early and midterm results.慢性缺血性二尖瓣反流的瓣环成形术:早期和中期结果令人鼓舞。
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Survival prognosis and surgical management of ischemic mitral regurgitation.缺血性二尖瓣反流的生存预后及外科治疗
Ann Thorac Surg. 2008 Sep;86(3):735-44. doi: 10.1016/j.athoracsur.2008.05.017.
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Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure.限制性二尖瓣环成形术可治愈缺血性二尖瓣反流和心力衰竭。
Ann Thorac Surg. 2008 Feb;85(2):430-6; discussion 436-7. doi: 10.1016/j.athoracsur.2007.08.040.
5
Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study.中度缺血性二尖瓣反流的早期修复可逆转左心室重构:一项功能与分子研究。
Circulation. 2007 Sep 11;116(11 Suppl):I288-93. doi: 10.1161/CIRCULATIONAHA.106.681114.
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Clinical outcomes of surgery of mitral valve regurgitation and coronary artery bypass grafting.二尖瓣反流手术和冠状动脉旁路移植术的临床结果。
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ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons.美国心脏病学会/美国心脏协会2006年瓣膜性心脏病患者管理指南:美国心脏病学会/美国心脏协会实践指南工作组(修订1998年瓣膜性心脏病患者管理指南写作委员会)报告,与心血管麻醉医师学会合作制定,得到心血管造影和介入学会及胸外科医师学会认可。
J Am Coll Cardiol. 2006 Aug 1;48(3):e1-148. doi: 10.1016/j.jacc.2006.05.021.
8
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Circulation. 2006 Jul 4;114(1 Suppl):I588-93. doi: 10.1161/CIRCULATIONAHA.105.001347.
9
Impact of moderate functional mitral insufficiency in patients undergoing surgical revascularization.中度功能性二尖瓣关闭不全对接受外科血运重建患者的影响。
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Ischemic mitral regurgitation: revascularization alone versus revascularization and mitral valve repair.缺血性二尖瓣反流:单纯血运重建与血运重建加二尖瓣修复
Ann Thorac Surg. 2005 Jun;79(6):1895-901. doi: 10.1016/j.athoracsur.2004.11.005.