利用枣花蜜作为片剂黏合剂的应用，对比研究。
Utilization of date syrup as a tablet binder, comparative study.
机构信息
Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
出版信息
Saudi Pharm J. 2010 Apr;18(2):81-9. doi: 10.1016/j.jsps.2010.02.003. Epub 2010 Feb 14.
The aim of this study was to investigate the possibility of using dates syrup as a tablet binder. Dates syrup (40%, 50%, 60% w/w dates syrup:water) was utilized for the granulation of sodium bicarbonate and calcium carbonate as examples for water-soluble and water-insoluble materials; correspondingly. Those two materials represent examples of bulky drugs as well. Starch paste (10% w/w starch in water) and sucrose syrup (50% w/w sucrose in water), the well-known tablet binders, were used in the granulation of the same materials for the sake of comparison. The granulations were evaluated with regard to particle size and particle size distribution, granule strength, bulk density, flowability, moisture content and compression behavior. In addition, tablets prepared and evaluated from these granules. Taste and flavor of the prepared tablet have been tested by seven healthy volunteers. Within the scope of this work, dates syrup showed excellent properties as a tablet binder in comparison to starch paste or sucrose syrup for the granulation of both water-soluble and water-insoluble materials. Also, better flavoring and masking taste have been noticed from an evaluation by human volunteers demonstrating the usefulness of the date syrup as sweetener and flavoring the tablets in addition to its use as binder.
本研究旨在探讨枣糖浆作为片剂黏合剂的可能性。枣糖浆（40%、50%、60%w/w 枣糖浆：水）用于碳酸氢钠和碳酸钙的造粒，分别作为水溶性和水不溶性物质的代表；相应地，这两种材料也代表了大体积药物的例子。淀粉糊（10%w/w 水中的淀粉）和蔗糖浆（50%w/w 水中的蔗糖），这两种众所周知的片剂黏合剂，也被用于相同材料的造粒，以便进行比较。对造粒物的粒度和粒度分布、颗粒强度、堆密度、流动性、水分含量和压缩行为进行了评估。此外，还从这些颗粒中制备和评估了片剂。由七位健康志愿者对制备的片剂的口感和味道进行了测试。在这项工作的范围内，与淀粉糊或蔗糖浆相比，枣糖浆在水溶性和水不溶性物质的造粒中表现出作为片剂黏合剂的优异性能。此外，志愿者的评估表明，枣糖浆除了用作黏合剂外，还可以作为甜味剂和调味片剂，从而获得更好的调味和掩盖味道。
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