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腺嘌呤核苷及其受体作为治疗靶点：概述。

Adenosine and its receptors as therapeutic targets: An overview.

机构信息

ASBASJSM College of Pharmacy, Bela, Ropar, India.

出版信息

Saudi Pharm J. 2013 Jul;21(3):245-53. doi: 10.1016/j.jsps.2012.05.011. Epub 2012 Jun 23.

DOI:10.1016/j.jsps.2012.05.011
PMID:23960840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3744929/
Abstract

The main goal of the authors is to present an overview of adenosine and its receptors, which are G-protein coupled receptors. The four known adenosine receptor subtypes are discussed along with the therapeutic potential indicating that these receptors can serve as targets for various dreadful diseases.

摘要

作者的主要目标是介绍腺苷及其受体的概述，这些受体是 G 蛋白偶联受体。讨论了四种已知的腺苷受体亚型，并探讨了其治疗潜力，表明这些受体可以作为各种可怕疾病的靶点。

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本文引用的文献

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Expert Opin Ther Pat. 2012 Apr;22(4):369-90. doi: 10.1517/13543776.2012.669375. Epub 2012 Mar 22.
2
Purinergic modulation of the excitatory synaptic input onto rat striatal neurons.嘌呤能调制大鼠纹状体神经元的兴奋性突触传入。
Neuropharmacology. 2012 Mar;62(4):1756-66. doi: 10.1016/j.neuropharm.2011.12.001. Epub 2011 Dec 13.
3
The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.新型的腺苷 A2A 拮抗剂 Lu AA47070 可逆转多巴胺 D2 受体阻断引起的运动和动机效应。
Pharmacol Biochem Behav. 2012 Jan;100(3):498-505. doi: 10.1016/j.pbb.2011.10.015. Epub 2011 Oct 20.
4
Alterations in vasoconstrictor responses to the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in DOCA-salt hypertensive rats.在 DOCA-盐高血压大鼠中，血管收缩反应对内皮衍生的收缩因子尿苷腺苷四磷酸的改变具有区域特异性。
Pharmacol Res. 2012 Jan;65(1):81-90. doi: 10.1016/j.phrs.2011.09.005. Epub 2011 Sep 14.
5
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.A(2A) 腺苷受体拮抗剂在帕金森病治疗中的过去、现在和未来。
Pharmacol Ther. 2011 Dec;132(3):280-99. doi: 10.1016/j.pharmthera.2011.07.004. Epub 2011 Jul 23.
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Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. doi: 10.1016/j.bmc.2010.01.072. Epub 2010 Feb 4.
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