Alkatan Hind M, Maktabi Azzah
Department of Pathology and Laboratory Medicine, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Saudi J Ophthalmol. 2010 Jan;24(1):23-6. doi: 10.1016/j.sjopt.2009.12.004. Epub 2010 Jan 4.
Retinoblastoma is one of the most important childhood tumors with genetic implications and necessity for family counseling and long term follow up. We are presenting a 22 year-old Saudi male with history of bilateral retinoblastoma, who was initially treated by enucleation of his left eye. The histopathology showed a moderately differentiated tumor with vitreous seeding and he received chemotherapy in addition to radiotherapy to his right eye. He presented 20 years later with a right orbital tumor, frozen globe and proptosis. The excisional biopsy of his orbital mass revealed a spindle cell sarcoma with features of malignant fibrous histiocytoma. His clinical and radiological findings are presented together with the histopathologic features of his orbital tumor and brief review of secondary tumors in retinoblastoma patients.
视网膜母细胞瘤是最重要的儿童肿瘤之一，具有遗传影响，需要进行家庭咨询和长期随访。我们报告一名22岁的沙特男性，有双侧视网膜母细胞瘤病史，其左眼最初接受了眼球摘除术。组织病理学显示为中度分化肿瘤伴玻璃体播散，除右眼接受放疗外，他还接受了化疗。20年后，他出现了右眼眶肿瘤、眼球固定和眼球突出。其眼眶肿物的切除活检显示为具有恶性纤维组织细胞瘤特征的梭形细胞肉瘤。本文展示了他的临床和影像学检查结果，以及眼眶肿瘤的组织病理学特征，并简要回顾了视网膜母细胞瘤患者的继发性肿瘤。
