Font R L, Hidayat A A
Hum Pathol. 1982 Mar;13(3):199-209. doi: 10.1016/s0046-8177(82)80178-0.
This is a clinicopathologic study of 150 cases of fibrous histiocytoma of the orbit. The tumors occurred in adults (median age, 43 years). The upper and nasal portions of the orbit were the most common sites of involvement. The most common signs and symptoms were proptosis (60 per cent), mass (46 per cent), and decreased vision (25 per cent). Based on the histopathologic features, the tumors were classified in three groups: benign (94 cases), locally aggressive (39 cases), and malignant (17 cases). The biological behavior correlated well with the duration of symptoms, the size and margins of the mass, and the histologic classification. The rate of recurrence was 31 per cent for the benign tumors, 57 per cent for the locally aggressive tumors, and 64 per cent for the malignant tumors. Follow-up data were obtained for 123 patients, with a mean duration of seven years. The ten-year survival of patients with benign, locally aggressive, and malignant fibrous histiocytoma was 100 per cent, 92 per cent, and 23 per cent, respectively. Nine patients died as a result of the tumor, six from local invasion of adjacent structures and three from metastatic disease. Fibrous histiocytoma is the most common primary mesenchymal orbital tumor of adults. The origin of the neoplasm is probably a primitive mesenchymal cell. Complete surgical excision appears to be the treatment of choice.
这是一项对150例眼眶纤维组织细胞瘤的临床病理研究。肿瘤发生于成年人（中位年龄43岁）。眼眶的上部和鼻侧部分是最常受累的部位。最常见的体征和症状是眼球突出（60%）、肿块（46%）和视力下降（25%）。根据组织病理学特征，肿瘤分为三组：良性（94例）、局部侵袭性（39例）和恶性（17例）。生物学行为与症状持续时间、肿块大小和边界以及组织学分类密切相关。良性肿瘤的复发率为31%，局部侵袭性肿瘤为57%，恶性肿瘤为64%。获得了123例患者的随访数据，平均随访时间为7年。良性、局部侵袭性和恶性纤维组织细胞瘤患者的10年生存率分别为100%、92%和23%。9例患者死于肿瘤，6例死于邻近结构的局部侵犯，3例死于转移性疾病。纤维组织细胞瘤是成年人最常见的原发性间质性眼眶肿瘤。肿瘤起源可能是原始间充质细胞。完整的手术切除似乎是首选治疗方法。
