Husebye E, O'Leary D, Skar V, Melby K
Dept. of Internal Medicine, Ullevål Hospital, Oslo, Norway.
Scand J Gastroenterol. 1990 Jul;25(7):725-30. doi: 10.3109/00365529008997599.
Detection of gastric Campylobacter by the 14C-urea breath test and serology were correlated to biopsy culture in 25 unselected outpatients referred for gastroscopy. All the 17 culture-positive patients had positive 14C-urea breath test, and 16 had positive serology. Of eight culture-negative patients, six patients had negative breath test and seven negative serology. A high degree of reproducibility was found when two subsequent breath tests were performed in 11 healthy volunteers. The breath test values obtained at 10 min showed a strong correlation (r = 0.97, p less than 0.001) to the accumulated values within 30 min. Breath sampling once, 10 min after intake of 2.5 microCi 14C-urea, seems sufficient for the detection of gastric Campylobacter. The 14C-urea breath test correlates well with biopsy culture and provides a sensitive tool for the detection of gastric Campylobacter. Serology also corresponds well with biopsy culture and should provide a useful tool for epidemiologic studies.
对25名因胃镜检查前来就诊的未经挑选的门诊患者，通过14C-尿素呼气试验和血清学检测幽门弯曲菌，并与活检培养结果进行相关性分析。17例培养阳性的患者14C-尿素呼气试验均为阳性，16例血清学检测呈阳性。8例培养阴性的患者中，6例呼气试验为阴性，7例血清学检测为阴性。对11名健康志愿者进行两次连续的呼气试验，发现其具有高度的可重复性。10分钟时获得的呼气试验值与30分钟内的累积值呈强相关性（r = 0.97，p < 0.001）。摄入2.5微居里14C-尿素10分钟后采集一次呼气样本，似乎足以检测出幽门弯曲菌。14C-尿素呼气试验与活检培养结果相关性良好，为检测幽门弯曲菌提供了一种敏感的方法。血清学检测结果也与活检培养结果相符，应为流行病学研究提供一种有用的方法。
