泪腺肿瘤的最新进展：相关分子病理学
Update on lacrimal gland neoplasms: Molecular pathology of interest.
作者信息
White Valerie A
机构信息
Department of Pathology and Laboratory Medicine and Ophthalmology and Visual Sciences, Vancouver Coastal Health and University of British Columbia, Vancouver, BC, Canada.
出版信息
Saudi J Ophthalmol. 2012 Apr;26(2):133-5. doi: 10.1016/j.sjopt.2012.02.012.
Abstract
Lacrimal gland neoplasms are rare and much of our knowledge of the behavior and molecular pathogenesis of these tumors comes from study of the similar, but more numerous salivary gland neoplasms. After briefly discussing the classification of lacrimal gland neoplasms, I review three areas of emerging knowledge in the pathogenesis of these neoplasms: (1) the concept of adenoid cystic carcinoma with high-grade transformation and the associated cytogenetic changes; (2) recent analysis of the MYB-NFIB gene fusion in adenoid cystic carcinoma, and; (3) overexpression of HER2 in malignant salivary and lacrimal neoplasms.
摘要
泪腺肿瘤较为罕见，我们对这些肿瘤的行为和分子发病机制的了解大多来自对相似但更为常见的涎腺肿瘤的研究。在简要讨论泪腺肿瘤的分类后，我将回顾这些肿瘤发病机制中三个新出现的知识领域：（1）具有高级别转化的腺样囊性癌概念及相关细胞遗传学改变；（2）腺样囊性癌中MYB-NFIB基因融合的最新分析；以及（3）HER2在恶性涎腺和泪腺肿瘤中的过表达。
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本文引用的文献
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Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation.腺样囊性癌伴高级别转化的进行性遗传改变。
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HER2: biology, detection, and clinical implications.人表皮生长因子受体 2（HER2）：生物学、检测及临床意义。
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Histologic grading and prognostic biomarkers in salivary gland carcinomas.涎腺癌的组织学分级和预后生物标志物。
Adv Anat Pathol. 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a.
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Am J Surg Pathol. 2011 Jan;35(1):92-9. doi: 10.1097/PAS.0b013e3182002777.
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