a Department of Biology , Payame Noor University , P.O. Box 19395-3697, Tehran , Iran.
Nat Prod Res. 2013;27(24):2292-6. doi: 10.1080/14786419.2013.827192. Epub 2013 Aug 20.
Snakin-Z is a novel antimicrobial peptide (AMP) that is identified from the fruit of Zizyphus jujuba. This peptide is composed of 31 amino acids which is determined with the sequence of CARLNCVPKGTSGNTETCPCYASLHSCRKYG and molecular weight of 3318.82 Da. Snakin-Z is not identical to any AMP in the peptide database. According to this study, Snakin-Z potentially has antimicrobial property against bacteria and fungi. Minimal inhibitory concentration (MIC) value of this peptide is suitable for antimicrobial activity. We assessed that Snakin-Z could affect Phomopsis azadirachtae with the MIC value of 7.65 μg/mL and vice versa Staphylococcus aureus with the MIC value of 28.8 μg/mL. Interestingly, human red blood cells also showed good tolerance to the Snakin-Z. On the basis of this study, Snakin-Z can be an appropriate candidate for therapeutic applications in the future due to its antimicrobial property.
蛇皮素-Z 是一种新型的抗菌肽 (AMP)，从枣(Zizyphus jujuba)的果实中被鉴定出来。该肽由 31 个氨基酸组成，序列为 CARLNCVPKGTSGNTETCPCYASLHSCRKYG，分子量为 3318.82 Da。蛇皮素-Z 与肽数据库中的任何 AMP 都不相同。根据这项研究，蛇皮素-Z 可能对细菌和真菌具有抗菌特性。该肽的最小抑菌浓度 (MIC) 值适合抗菌活性。我们评估了蛇皮素-Z 对 7.65 μg/mL 的 MIC 值的印度紫檀 Phomopsis azadirachtae 有影响，而对 28.8 μg/mL 的 MIC 值的金黄色葡萄球菌有相反的影响。有趣的是，人红细胞对蛇皮素-Z 也表现出良好的耐受性。基于这项研究，由于其抗菌特性，蛇皮素-Z 未来可能成为治疗应用的合适候选物。
