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植物肽及其在人类健康中的应用的最新综述

The Updated Review on Plant Peptides and Their Applications in Human Health.

作者信息

Mani Saiprahalad, Bhatt Smruti B, Vasudevan Vinduja, Prabhu Dhamodharan, Rajamanikandan Sundararaj, Velusamy Palaniyandi, Ramasamy Palaniappan, Raman Pachaiappan

机构信息

Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Tamil Nadu 603 203 India.

Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu 600 044 India.

出版信息

Int J Pept Res Ther. 2022;28(5):135. doi: 10.1007/s10989-022-10437-7. Epub 2022 Jul 27.

Abstract

Biologically active plant peptides, consisting of secondary metabolites, are compounds (amino acids) utilized by plants in their defense arsenal. Enzymatic processes and metabolic pathways secrete these plant peptides. They are also known for their medicinal value and have been incorporated in therapeutics of major human diseases. Nevertheless, its limitations (low bioavailability, high cytotoxicity, poor absorption, low abundance, improper metabolism, etc.) have demanded a need to explore further and discover other new plant compounds that overcome these limitations. Keeping this in mind, therapeutic plant proteins can be excellent remedial substitutes for bodily affliction. A multitude of these peptides demonstrates anti-carcinogenic, anti-microbial, anti-HIV, and neuro-regulating properties. This article's main aim is to list out and report the status of various therapeutic plant peptides and their prospective status as peptide-based drugs for multiple diseases (infectious and non-infectious). The feasibility of these compounds in the imminent future has also been discussed.

摘要

由次生代谢产物组成的具有生物活性的植物肽是植物防御武器库中使用的化合物(氨基酸)。酶促过程和代谢途径分泌这些植物肽。它们还因其药用价值而闻名,并已被纳入主要人类疾病的治疗方法中。然而,其局限性(低生物利用度、高细胞毒性、吸收不良、丰度低、代谢不当等)要求进一步探索并发现其他克服这些局限性的新型植物化合物。考虑到这一点,治疗性植物蛋白可以成为身体疾病的优秀替代治疗方法。许多这类肽具有抗癌、抗菌、抗艾滋病毒和神经调节特性。本文的主要目的是列出并报告各种治疗性植物肽的现状及其作为多种疾病(传染性和非传染性)基于肽的药物的潜在地位。还讨论了这些化合物在不久的将来的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c763/9326430/911fd25b64c9/10989_2022_10437_Fig1_HTML.jpg

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