Xu Wu-Jian, Shen Guo-Qing, Li Qiang
Department of Respiratory Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; China People's Liberation Army 73676, Wuxi 214162, China. E-mail:
Sheng Li Xue Bao. 2013 Aug 25;65(4):445-50.
Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues, and is mainly located in endoplasmic reticulum and cell membrane. Previous studies have revealed that Nogo-B plays a key role in vascular injury, tissue repair and inflammation process. It also may be critical for apoptosis of tumor cells and central diseases. Further investigation of the molecular characteristics and biological function of Nogo-B might be of great help to understand its role in diverse diseases.
Nogo-B是网状蛋白家族4的主要家族成员。它在中枢神经系统和外周组织中广泛表达，主要位于内质网和细胞膜。先前的研究表明，Nogo-B在血管损伤、组织修复和炎症过程中起关键作用。它对肿瘤细胞凋亡和中枢性疾病也可能至关重要。进一步研究Nogo-B的分子特征和生物学功能可能有助于理解其在多种疾病中的作用。
