Zhu Ying, Zhang Li-Qun, Li Jian-Dong
Department of Respiratory and Critical Care Medicine, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China.
Sheng Li Xue Bao. 2022 Apr 25;74(2):301-308.
Nogo-B receptor (NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.
Nogo-B受体（NgBR）是网织红细胞4蛋白家族成员Nogo-B的特异性受体。它在许多组织中广泛表达，主要位于细胞膜和内质网。先前的研究表明，NgBR参与多种生理和病理生理过程，如多萜醇合成、脂质代谢、胆固醇转运、胰岛素抵抗、血管重塑和血管生成、肿瘤发生以及神经系统疾病。对NgBR的分子特征和生物学功能进行进一步研究，可能对理解其在多种疾病中的作用具有重要意义，并为疾病治疗提供可能的临床策略。
