Mavrichev A S, Fradkin S Z, Zhavrid E A, Nodel'son S E, Rovbut' I I
Urol Nefrol (Mosk). 1990 May-Jun(3):48-52.
The attempt of treatment for metastatic renal cancer has not been a success as all the methods known failed to produce any significant effect on the development of metastases. So the search for the means which could potentiate the antitumor activity of the drugs or radiation therapy is still a problem. Various physicochemical methods, including hyperthermia and hyperglycemia, have been used as modifiers of tumor cell responses. When properly employed, hyperthermia and hyperglycemia can produce an antitumor effect. However, their ability to selectively potentiate radiation or chemotherapy is more valuable. A total of 25 patients with renal cell carcinoma and multiple metastases have undergone a comprehensive treatment: radiation therapy for metastases at the total dosage of 60 Gr after removal of the primary tumor. The session of hyperthermia and hyperglycemia was performed in the course of the radiation therapy. During the session chemotherapeutic agents were administered in a half-course dosage. The second part of the radiation therapy was continued after the session. The treatment course included 5 sessions and lasted 12 months. An immediate stabilization of the health status was recorded in all the patients. Some of them had the total or partial regression of metastases. Yet since the follow-up time was not long the authors could make no conclusions.
转移性肾癌的治疗尝试尚未成功，因为所有已知方法对转移灶的发展均未产生任何显著效果。因此，寻找能够增强药物或放射治疗抗肿瘤活性的方法仍然是一个问题。包括热疗和高血糖在内的各种物理化学方法已被用作肿瘤细胞反应的调节剂。如果使用得当，热疗和高血糖可以产生抗肿瘤作用。然而，它们选择性增强放疗或化疗的能力更具价值。共有25例肾细胞癌伴多发转移的患者接受了综合治疗：在切除原发肿瘤后，对转移灶进行总剂量为60戈瑞的放射治疗。在放射治疗过程中进行热疗和高血糖治疗。治疗期间，化疗药物以半程剂量给药。热疗和高血糖治疗结束后继续进行放射治疗的第二部分。治疗疗程包括5次治疗，持续12个月。所有患者的健康状况均立即得到稳定。其中一些患者的转移灶出现了完全或部分消退。然而，由于随访时间不长，作者无法得出结论。
