合成及某些新型嘧啶的抗组胺活性。
Synthesis and anti-histaminic activity of some novel pyrimidines.
机构信息
Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada 520 010, AP, India.
出版信息
Saudi Pharm J. 2009 Jul;17(3):255-8. doi: 10.1016/j.jsps.2009.08.001.
Abstract
Novel pyrimidines were prepared by the condensation of chalcones of 4'-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1-5 were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.
摘要
新型嘧啶类化合物是由 4'-哌嗪苯乙酮查耳酮与盐酸胍缩合而成。根据元素分析、IR、(1)H NMR 和质谱，确定了合成化合物 RP 1-5 的结构。这些化合物还进行了抗组胺活性筛选。与参考抗组胺药哌啶嗪相比，记录的组胺抑制百分率显示出显著的抗组胺活性。
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