合成含 2-氨基-6-甲氧基苯并噻唑的新型 4-噻唑烷酮衍生物及其抗菌活性。
Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole.
机构信息
Organic Research Laboratory, Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India.
出版信息
Saudi Pharm J. 2010 Jul;18(3):129-36. doi: 10.1016/j.jsps.2010.05.002. Epub 2010 Jun 2.
Abstract
A novel series of Schiff bases 5a-j and 4-thiazolidinones 6a-j have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [1] and 2-amino-6-methoxy-benzothiazole [2]. All of the synthesized compounds have been confirmed by elemental analyses, IR, (1)H NMR and (13)C NMR spectral data. These newly synthesized compounds were screened for their antimicrobial activity. Variable and modest activity was observed against the investigated strains of bacteria and fungi, however, compound 6h revealed significant antibacterial activity against Escherichia coli. Compounds 1, 2, 3, 5c, 5g and 5h, on the other hand, revealed potent antifungal activity against Candida albicans compared to the reference drug greseofulvin.
摘要
新型希夫碱 5a-j 和 4-噻唑烷酮 6a-j 系列已由 2-氯吡啶-3-羧酸[1]和 2-氨基-6-甲氧基苯并噻唑[2]这两种构建模块制备而成。所有合成的化合物都已通过元素分析、IR、(1)H NMR 和 (13)C NMR 光谱数据得到证实。这些新合成的化合物已对其抗菌活性进行了筛选。对所研究的细菌和真菌菌株的活性存在可变性和适度性，然而，化合物 6h 对大肠杆菌表现出显著的抗菌活性。另一方面，与参考药物灰黄霉素相比，化合物 1、2、3、5c、5g 和 5h 对白色念珠菌具有很强的抗真菌活性。
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