Synthesis of novel Schiff bases containing arylpyrimidines as promising antibacterial agents.

Pursuing our recent interest regarding the antimicrobial activity of Schiff bases derivatives, we have synthesized a series of 6-(substitutedphenyl)--(()-(substitutedphenyl)methylidene)-2-methylpyridine-3-carbohydrazides () and evaluated their antibacterial activity. Structures of these compounds were confirmed by standard studies of FTIR, H NMR, C NMR, MS and elemental analysis. Antibacterial activity of synthesized molecules was tested against Gram-positive ( and ) and Gram-negative ( and ) bacterial strains. Synthesized compounds showed good antibacterial activity at a lower concentration than standard. Most of the compounds (, , , and ) are potent against all the tested bacterial strains with MIC values ranging from 1.56-12.5 μg/mL.