Nayak Soukhyarani Gopal, Poojary Boja
Department of Chemistry, Mangalore University, Mangalagangothri, Mangaluru, 574199, Karnataka, India.
Heliyon. 2019 Aug 20;5(8):e02318. doi: 10.1016/j.heliyon.2019.e02318. eCollection 2019 Aug.
Pursuing our recent interest regarding the antimicrobial activity of Schiff bases derivatives, we have synthesized a series of 6-(substitutedphenyl)--(()-(substitutedphenyl)methylidene)-2-methylpyridine-3-carbohydrazides () and evaluated their antibacterial activity. Structures of these compounds were confirmed by standard studies of FTIR, H NMR, C NMR, MS and elemental analysis. Antibacterial activity of synthesized molecules was tested against Gram-positive ( and ) and Gram-negative ( and ) bacterial strains. Synthesized compounds showed good antibacterial activity at a lower concentration than standard. Most of the compounds (, , , and ) are potent against all the tested bacterial strains with MIC values ranging from 1.56-12.5 μg/mL.
基于我们近期对席夫碱衍生物抗菌活性的兴趣，我们合成了一系列6 -（取代苯基）-（（E）-（取代苯基）亚甲基）-2 -甲基吡啶-3 -碳酰肼（），并评估了它们的抗菌活性。通过傅里叶变换红外光谱（FTIR）、氢核磁共振（¹H NMR）、碳核磁共振（¹³C NMR）、质谱（MS）和元素分析等标准研究确定了这些化合物的结构。测试了合成分子对革兰氏阳性菌（金黄色葡萄球菌和枯草芽孢杆菌）和革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）菌株的抗菌活性。合成的化合物在比标准品更低的浓度下显示出良好的抗菌活性。大多数化合物（，，，和）对所有测试的细菌菌株都有强效作用，最低抑菌浓度（MIC）值范围为1.56 - 12.5μg/mL。
