Rashaed Saba Al, Rushood Abdulaziz
Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Saudi J Ophthalmol. 2013 Jan;27(1):55-7. doi: 10.1016/j.sjopt.2012.04.002. Epub 2012 Apr 28.
A case report of a 52 year old male who received intravitreal bevacizumab and developed culture positive endophthalmitis. Vitreous culture indicated that endophthalmitis was caused by Staphylococcus epidermidis. The patient was initially managed with intravitreal injection of ceftazidime and vancomycin, followed by pars plana lensectomy, pars plana vitrectomy with intravitreal injection of 1 mg/0.1 ml vancomycin, 2.25 mg/0.1 ml ceftazidime, 5 mg/0.1 ml fortified amphotericin-B and 4 mg/0.1 ml dexamethasone. Postoperatively the patient improved significantly. However, vision improved from hand motion to counting fingers secondary to severe retinal ischemia. Acute endophthalmitis can develop after intravitreal bevacizumab injections and cause profound visual loss. A review of literature was also performed for similar cases.
一名52岁男性接受玻璃体内注射贝伐单抗后发生培养阳性的眼内炎的病例报告。玻璃体培养表明眼内炎由表皮葡萄球菌引起。患者最初接受玻璃体内注射头孢他啶和万古霉素治疗，随后进行了晶状体平坦部切除术、晶状体平坦部玻璃体切除术，并玻璃体内注射1mg/0.1ml万古霉素、2.25mg/0.1ml头孢他啶、5mg/0.1ml强化两性霉素B和4mg/0.1ml地塞米松。术后患者明显好转。然而，由于严重的视网膜缺血，视力从手动改善为指数。玻璃体内注射贝伐单抗后可发生急性眼内炎并导致严重视力丧失。还对类似病例进行了文献综述。
