Belovezhdov N, Monova D, Altŭnkova I, Robeva R
Vutr Boles. 1990;29(1):59-68.
The initial results of the treatment of 8 patients with idiopathic and lupus glomerulonephritis with immunovenin intact are reported. Previously the patients had been treated for a long time with combinations of corticosteroids, immunosuppressors and anticoagulants without effect. All patients had an well expressed nephrotic syndrome, 6 patients had initial chronic renal failure. The immunovenin intact treatment was carried out in three day courses of 85 mg/kg/24 h (a total of 250 mg/kg for one course). All patients received two courses of treatment. The patients were followed up for 3 to 30 months (mean 10.0 +/- 3.29). In 4 patients a full clinical remission was achieved. Two patients, after a satisfactory effect of the treatment, died from non-renal causes. The mechanisms of action of immunovenin intact are discussed.
报告了8例特发性和狼疮性肾小球肾炎患者采用完整免疫球蛋白治疗的初步结果。此前，这些患者长期接受皮质类固醇、免疫抑制剂和抗凝剂联合治疗但无效。所有患者均有明显的肾病综合征，6例患者起初患有慢性肾衰竭。完整免疫球蛋白治疗以85mg/kg/24小时的三日疗程进行（一个疗程共250mg/kg）。所有患者接受两个疗程的治疗。对患者进行了3至30个月的随访（平均10.0±3.29）。4例患者实现了完全临床缓解。2例患者在治疗取得满意效果后死于非肾脏原因。讨论了完整免疫球蛋白的作用机制。
