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[使用氟化钠联合维生素D2和葡萄糖酸钙治疗绝经后及类固醇诱导的骨质疏松症患者]

[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate].

作者信息

Todorova S, Diankova L, Andreeva M, Khristova D, Tsachev K, Kamenova P

出版信息

Vutr Boles. 1990;29(1):77-81.

PMID:2396420
Abstract

9 patients with postmenopausal and 5 patients with steroid-induced osteoporosis, mean age 57.9 +/- 7.76 years, were treated in the course of one year with sodium fluoride (Fluosen) in a dose of 45 mg/24 h in combination with calcium gluconate (2 g/24 h) and oil solution of vit D2 (2 mg/week). In the course of the treatment a considerable easing of the pains in the most affected parts of the skeleton was found and the height remained at the same level before and after the treatment. This correlates with the statistically significant increase of the serum levels of the total alkaline phosphatase and its bone isoenzyme by keeping a normal kalium phosphorous balance as well as with the x-ray data for retaining the bone changes liked with the osteoporosis.

摘要

9名绝经后骨质疏松患者和5名类固醇诱导的骨质疏松患者,平均年龄57.9±7.76岁,在一年的疗程中接受了剂量为45毫克/24小时的氟化钠(氟羟强的松龙)治疗,同时联合葡萄糖酸钙(2克/24小时)和维生素D2油溶液(2毫克/周)。在治疗过程中,发现骨骼最受影响部位的疼痛明显减轻,治疗前后身高保持在同一水平。这与血清总碱性磷酸酶及其骨同工酶水平的统计学显著升高相关,同时保持了正常的钾磷平衡,也与保留与骨质疏松相关的骨骼变化的x光数据相关。

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