Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee Dundee, UK.
Front Synaptic Neurosci. 2013 Aug 6;5:3. doi: 10.3389/fnsyn.2013.00003. eCollection 2013.
The central actions of the hormone leptin in regulating energy homeostasis via the hypothalamus are well documented. However, evidence is growing that this hormone can also modify the structure and function of synapses throughout the CNS. The hippocampus is a region of the forebrain that plays a crucial role in associative learning and memory and is an area also highly vulnerable to neurodegenerative processes. Recent studies indicate that leptin is a potential cognitive enhancer as it modulates the cellular processes underlying hippocampal-dependent learning and memory including dendritic morphology, glutamate receptor trafficking and activity-dependent synaptic plasticity. Here, we review the recent evidence implicating the hormone leptin as a key regulator of hippocampal synaptic function and discuss the role of leptin receptor-driven lipid signaling pathways involved in this process.
瘦素作为一种激素，通过下丘脑对能量稳态进行调节的中枢作用已得到充分证实。然而，越来越多的证据表明，这种激素还可以改变中枢神经系统中突触的结构和功能。海马体是大脑前脑的一个区域，在联想学习和记忆中起着至关重要的作用，也是易受神经退行性过程影响的区域。最近的研究表明，瘦素是一种潜在的认知增强剂，因为它可以调节海马体依赖的学习和记忆的细胞过程，包括树突形态、谷氨酸受体运输和活性依赖性突触可塑性。在这里，我们回顾了最近的证据，这些证据表明激素瘦素是海马体突触功能的关键调节剂，并讨论了涉及该过程的瘦素受体驱动的脂质信号通路的作用。
