Modulation of T lymphocyte calcium influx patterns via the inhibition of kv1.3 and ikca1 potassium channels in autoimmune disorders.
作者信息
Orbán Csaba, Biró Enikõ, Grozdics Enikõ, Bajnok Anna, Toldi Gergely
机构信息
First Department of Pediatrics, Semmelweis University , Budapest, Hungary.
出版信息
Front Immunol. 2013 Aug 6;4:234. doi: 10.3389/fimmu.2013.00234. eCollection 2013.
Abstract
摘要
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Modulation of T lymphocyte calcium influx patterns via the inhibition of kv1.3 and ikca1 potassium channels in autoimmune disorders.通过抑制自身免疫性疾病中的Kv1.3和IKCa1钾通道来调节T淋巴细胞钙内流模式
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本文引用的文献
1
The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis.Kv1.3 和 IKCa1 钾通道抑制对类风湿关节炎患者外周血 T 淋巴细胞钙离子内流的影响。
Immunobiology. 2013 Mar;218(3):311-6. doi: 10.1016/j.imbio.2012.05.013. Epub 2012 May 23.
2
Lymphocyte calcium influx kinetics in multiple sclerosis treated without or with interferon β.多发性硬化症患者在未接受或接受干扰素β治疗时的淋巴细胞钙离子内流动力学。
J Neuroimmunol. 2011 Aug 15;237(1-2):80-6. doi: 10.1016/j.jneuroim.2011.06.008. Epub 2011 Jul 20.
3
Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels.1 型糖尿病中的淋巴细胞活化：Kv1.3 钾通道的重要性增加。
Immunol Lett. 2010 Sep 6;133(1):35-41. doi: 10.1016/j.imlet.2010.06.009. Epub 2010 Jul 13.
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Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.Kv1.3 钾通道作为多发性硬化症的治疗靶点。
Expert Opin Ther Targets. 2009 Aug;13(8):909-24. doi: 10.1517/14728220903018957.
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Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients.健康受试者和多发性硬化症患者的人类CD4 +调节性T细胞和初始T细胞中的钾通道表达。
Immunol Lett. 2009 Jun 4;124(2):95-101. doi: 10.1016/j.imlet.2009.04.008. Epub 2009 May 3.
6
Cytometry-acquired calcium-flux data analysis in activated lymphocytes.活化淋巴细胞中细胞计数法获取的钙流数据分析。
Cytometry A. 2008 Mar;73(3):246-53. doi: 10.1002/cyto.a.20518.
7
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.Kv1.3通道是T细胞介导的自身免疫性疾病的治疗靶点。
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9. doi: 10.1073/pnas.0605136103. Epub 2006 Nov 6.
8
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.电压门控钾通道Kv1.3在多发性硬化症脑内的炎性浸润物上高度表达。
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11094-9. doi: 10.1073/pnas.0501770102. Epub 2005 Jul 25.
9
K+ channels as targets for specific immunomodulation.钾离子通道作为特异性免疫调节的靶点。
Trends Pharmacol Sci. 2004 May;25(5):280-9. doi: 10.1016/j.tips.2004.03.010.
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The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.效应记忆T细胞中的电压门控Kv1.3钾离子通道作为多发性硬化症的新靶点。
J Clin Invest. 2003 Jun;111(11):1703-13. doi: 10.1172/JCI16921.
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