Thiele G, Bürkmann I, Ziesenhenn K, Herold B
Klinik für Innere Medizin, Bezirkskrankenhauses St. Georg Leipzig.
Z Gesamte Inn Med. 1990 Jun 15;45(11):315-8.
On the basis of 10 patients with chronic cor pulmonale due to chronic obstructive lung disease and secondary polyglobulia in a clinical and experimental study could be made evident that by limited isovolaemic haemodilution (haematocrit value of 0.58 +/- 0.03 reduced to 0.36 +/- 0.01) are to be expected a decrease of the total pulmonary-arterial resistance, a reduction of the mean pulmonary arterial pressure, an increase of the partial O2-pressure as well as an increase of the heart index. Analogically to this as a consequence of the improved rheologic conditions a clear involution of the clinical signs of a heart insufficiency developed. Complications were not observed. The technique of the limited haemodilution should find a broader use in the medical practice, taking into consideration the isovolaemia as adjuvant treatment principle for patients with the indication mentioned.
基于对10例因慢性阻塞性肺疾病导致慢性肺心病并继发红细胞增多症患者的临床和实验研究，可以明显看出，通过有限的等容血液稀释（血细胞比容值从0.58±0.03降至0.36±0.01），预计总肺动脉阻力会降低，平均肺动脉压会降低，氧分压会升高，心指数会升高。与此类似，由于血液流变学状况改善，心力衰竭的临床症状明显消退。未观察到并发症。考虑到等容性作为上述适应症患者的辅助治疗原则，有限血液稀释技术应在医学实践中得到更广泛的应用。
