Department of Experimental Clinical Oncology, Aarhus University Hospital , Aarhus , Denmark.
Acta Oncol. 2013 Oct;52(7):1543-51. doi: 10.3109/0284186X.2013.822553. Epub 2013 Aug 22.
Loss of lean body mass is common following radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and may reduce maximal muscle strength and functional performance. However, the associations between lean body mass, muscle strength and functional performance are unclear and no studies in HNSCC patients have compared the levels of these variables to the levels seen in healthy individuals.
The purpose of the present study was to investigate the associations between lean body mass, maximal muscle strength and functional performance in HNSCC patients and to compare the levels of these variables after radiotherapy and after progressive resistance training with the levels in healthy individuals.
Lean body mass (dual energy X-ray absorptiometry), maximal muscle strength (isokinetic dynamometry) and functional performance (10 m max gait speed, 30 s chair rise, 30 s arm curl, stair climb) from HNSCC patients from the DAHANCA 25 trials and data from 24 healthy individuals were included.
Lean body mass and maximal muscle strength were significantly associated according to the gender and age-adjusted linear regression model (p < 0.0001). In addition, maximal muscle strength were associated with 30 s arm curl performance, 10 m max gait speed and 30 s chair rise (p < 0.0001). Multiple regression analyses showed that HNSCC patients expressed significant lower levels of the investigated variables after radiotherapy than healthy individuals (p < 0.0001), and that all differences were evened out after training.
Significant associations were found between lean body mass, maximal muscle strength and functional performance in HNSCC patients. Patients expressed lower levels of these variables compared with healthy individuals, suggesting that lean body mass is a clinically relevant health factor in HNSCC patients.
头颈部鳞状细胞癌（HNSCC）患者在接受放射治疗后，常会出现去脂体重减少的情况，这可能会降低最大肌肉力量和功能表现。然而，去脂体重、肌肉力量和功能表现之间的相关性尚不清楚，且 HNSCC 患者中尚无研究比较这些变量与健康个体之间的水平。
本研究旨在探讨 HNSCC 患者去脂体重、最大肌肉力量和功能表现之间的相关性，并比较放射治疗后和渐进式抗阻训练后这些变量的水平与健康个体的水平。
纳入 DAHANCA 25 试验中的 HNSCC 患者和 24 名健康个体的去脂体重（双能 X 射线吸收法）、最大肌肉力量（等速测力法）和功能表现（10 m 最大步速、30 秒坐起、30 秒手臂卷曲、爬楼梯）数据。
根据性别和年龄调整的线性回归模型，去脂体重和最大肌肉力量显著相关（p<0.0001）。此外，最大肌肉力量与 30 秒手臂卷曲表现、10 m 最大步速和 30 秒坐起相关（p<0.0001）。多元回归分析显示，与健康个体相比，HNSCC 患者在接受放射治疗后表现出明显较低的研究变量水平（p<0.0001），而所有差异在训练后均得到平衡。
在 HNSCC 患者中，去脂体重、最大肌肉力量和功能表现之间存在显著相关性。与健康个体相比，患者这些变量的水平较低，表明去脂体重是 HNSCC 患者的一个具有临床意义的健康因素。
