Lønbro Simon, Dalgas Ulrik, Primdahl Hanne, Johansen Jørgen, Nielsen Jakob Lindberg, Aagaard Per, Hermann Anne Pernille, Overgaard Jens, Overgaard Kristian
Dept. of Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Dept. of Public Health, Section for Sport Science, Aarhus University, Denmark.
Radiother Oncol. 2013 Aug;108(2):314-9. doi: 10.1016/j.radonc.2013.07.002. Epub 2013 Aug 6.
The critical weight loss observed in head and neck squamous cell carcinoma (HNSCC) patients following radiotherapy is mainly due to loss of lean body mass. This is associated with decreases in muscle strength, functional performance and Quality of Life (QoL). The present study investigated the effect of progressive resistance training (PRT) on lean body mass, muscle strength and functional performance in HNSCC patients following radiotherapy.
Following radiotherapy HNSCC patients were randomized into two groups: Early Exercise (EE, n=20) initiated 12 weeks of PRT followed by 12 weeks of self-chosen physical activity. Delayed Exercise (DE, n=21) initiated 12 weeks of self-chosen physical activity followed by 12 weeks of PRT. Lean body mass, muscle strength, functional performance and QoL were evaluated at baseline and after week 12 and 24.
In the first 12 weeks lean body mass increased by 4.3% in EE after PRT and in the last 12 weeks by 4.2% in DE after PRT. These increases were significantly larger than the changes after self-chosen physical activity (p ≤ 0.005). Regardless of PRT start-up time, the odds ratio of increasing lean body mass by more than 4% after PRT was 6.26 (p<0.05). PRT significantly increased muscle strength, whereas functional performance increased significantly more than after self-chosen physical activity only after delayed onset of PRT. Overall QoL improved significantly more in EE than DE from baseline to week 12.
PRT effectively increased lean body mass and muscle strength in HNSCC patients following radiotherapy, irrespectively of early or delayed start-up.
头颈部鳞状细胞癌（HNSCC）患者放疗后出现的严重体重减轻主要是由于去脂体重的减少。这与肌肉力量、功能表现和生活质量（QoL）的下降有关。本研究调查了渐进性抗阻训练（PRT）对放疗后HNSCC患者去脂体重、肌肉力量和功能表现的影响。
放疗后，HNSCC患者被随机分为两组：早期运动组（EE，n = 20），先进行12周的PRT，然后进行12周的自主选择体育活动。延迟运动组（DE，n = 21），先进行12周的自主选择体育活动，然后进行12周的PRT。在基线、第12周和第24周后评估去脂体重、肌肉力量、功能表现和QoL。
在最初的12周，EE组在PRT后去脂体重增加了4.3%，在最后的12周，DE组在PRT后增加了4.2%。这些增加显著大于自主选择体育活动后的变化（p≤0.005）。无论PRT的启动时间如何，PRT后去脂体重增加超过4%的优势比为6.26（p<0.05）。PRT显著增加了肌肉力量，而功能表现仅在PRT延迟开始后比自主选择体育活动增加得更显著。从基线到第12周，EE组的总体QoL改善明显大于DE组。
PRT能有效增加放疗后HNSCC患者的去脂体重和肌肉力量，无论开始时间是早还是晚。
