Department of Internal Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.
Department of Medical Oncology, Hacettepe University, Cancer Institute, Ankara, Turkey.
Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3541-3556. doi: 10.1007/s00405-023-08014-9. Epub 2023 May 15.
The purpose of this article is to provide an up-to-date summary of sarcopenia and its clinical implications for patients with head and neck cancer (HNC).
We conducted a literature review of recent studies investigating the prevalence of sarcopenia in HNC patients, its detection using MRI or CT scans, and its association with clinical outcomes such as disease-free and overall survival time, radiotherapy-related side effects, cisplatin toxicity, and surgical complications.
Sarcopenia, characterized by low skeletal muscle mass (SMM), is a prevalent condition in HNC patients and can be effectively detected using routine MRI or CT scans. Low SMM in HNC patients is associated with increased risks of shorter disease-free and overall survival times, as well as radiotherapy-related side effects such as mucositis, dysphagia, and xerostomia. In addition, cisplatin toxicity is more severe in HNC patients with low SMM, leading to higher dose-limiting toxicity and treatment interruptions. Low SMM may also predict higher risks of surgical complications in head and neck surgery. Identifying sarcopenic patients can aid physicians in better riskstratifying HNC patients for therapeutic or nutritional interventions to improve clinical outcomes.
Sarcopenia is a significant concern for HNC patients and can impact their clinical outcomes. Routine MRI or CT scans can effectively detect low SMM in HNC patients. Identifying sarcopenic patients can aid physicians in better risk-stratifying HNC patients for therapeutic or nutritional interventions to improve clinical outcomes. Further research is needed to explore the potential of interventions to mitigate the negative effects of sarcopenia in HNC patients.
本文旨在提供肌少症及其对头颈部癌症（HNC）患者的临床意义的最新综述。
我们对最近研究肌少症在 HNC 患者中的流行情况、使用 MRI 或 CT 扫描检测肌少症以及肌少症与无病生存期和总生存期、放疗相关副作用、顺铂毒性和手术并发症等临床结果之间的关系进行了文献回顾。
肌少症的特征是骨骼肌量低（SMM），在 HNC 患者中较为普遍，可通过常规 MRI 或 CT 扫描有效检测。HNC 患者的 SMM 较低与无病生存期和总生存期较短、放疗相关副作用（如黏膜炎、吞咽困难和口干）的风险增加有关。此外，SMM 较低的 HNC 患者顺铂毒性更严重，导致更高的剂量限制毒性和治疗中断。SMM 较低也可能预示着头颈外科手术中更高的手术并发症风险。识别肌少症患者可以帮助医生更好地对 HNC 患者进行风险分层，以便进行治疗或营养干预，以改善临床结果。
肌少症是 HNC 患者的一个重要关注点，可能会影响其临床结果。常规 MRI 或 CT 扫描可有效检测 HNC 患者的 SMM 较低。识别肌少症患者可以帮助医生更好地对 HNC 患者进行风险分层，以便进行治疗或营养干预，以改善临床结果。需要进一步研究探索干预措施减轻肌少症对 HNC 患者的负面影响的潜力。
