Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F, Ap Lei Chau Clinic, 161 Ap Lei Chau Main Street, Ap Lei Chau, Hong Kong.
Health Qual Life Outcomes. 2013 Aug 21;11:142. doi: 10.1186/1477-7525-11-142.
This study aimed to determine the associations of various clinical factors with generic health-related quality of life (HRQOL) scores among Hong Kong Chinese patients with type 2 diabetes mellitus (T2DM) in the outpatient primary care setting using the short-form 12 (SF-12).
A cross-sectional survey of 488 Chinese adults with T2DM recruited from a primary care outpatient clinic was conducted from May to August 2008. Data on the standard Chinese (HK) SF-12 Health Survey and patients' socio-demographics were collected from face-to-face interviews. Glycaemic control, body mass index (BMI), chronic co-morbidities, diabetic complications and treatment modalities were determined for each patient through medical records. Associations of socio-demographic and clinical factors with physical component summary (PCS-12) and mental component summary scores (MCS-12) were evaluated using multiple linear regression.
The socio-demographic correlates of PCS-12 and MCS-12 were age, gender and BMI. After adjustment for socio-demographic variables, the BMI was negatively associated with PCS-12 but positively associated with MCS-12. The presence of diabetic complications was associated with lower PCS-12 (regression coefficient:-3.0 points, p < 0.05) while being on insulin treatment was associated with lower MCS-12 (regression coefficient:-5.8 points, p < 0.05). In contrast, glycaemic control, duration of T2DM and treatment with oral hypoglycaemic drugs were not significantly associated with PCS-12 or MCS-12.
Among T2DM subjects in the primary care setting, impairments in the physical aspect of HRQOL were evident in subjects who were obese or had diabetic complications whereas defects in the mental aspect of HRQOL were observed in patients with lower BMI or receiving insulin injections.
本研究旨在使用简明 12 项健康调查量表（SF-12），确定各种临床因素与香港中文 2 型糖尿病患者（T2DM）门诊初级保健环境下一般健康相关生活质量（HRQOL）评分之间的关系。
2008 年 5 月至 8 月，对从初级保健门诊招募的 488 名中国成年 T2DM 患者进行了横断面调查。通过面对面访谈收集了标准中文（HK）SF-12 健康调查和患者社会人口统计学数据。通过病历确定每位患者的血糖控制、体重指数（BMI）、慢性合并症、糖尿病并发症和治疗方式。使用多元线性回归评估社会人口统计学和临床因素与生理成分综合评分（PCS-12）和心理成分综合评分（MCS-12）之间的关系。
PCS-12 和 MCS-12 的社会人口统计学相关性因素为年龄、性别和 BMI。在调整社会人口统计学变量后，BMI 与 PCS-12 呈负相关，与 MCS-12 呈正相关。存在糖尿病并发症与较低的 PCS-12 相关（回归系数：-3.0 分，p < 0.05），而使用胰岛素治疗与较低的 MCS-12 相关（回归系数：-5.8 分，p < 0.05）。相比之下，血糖控制、T2DM 病程和口服降糖药治疗与 PCS-12 或 MCS-12 无显著相关性。
在初级保健环境中的 T2DM 患者中，身体方面的 HRQOL 受损明显见于肥胖或存在糖尿病并发症的患者，而心理方面的 HRQOL 缺陷见于 BMI 较低或接受胰岛素注射的患者。
