Shakeel Faiyaz, Haq Nazrul, Alanazi Fars K, Alsarra Ibrahim A
Center of Excellence in Biotechnology Research, King Saud University , P.O. Box 2460, Riyadh 11451 , Saudi Arabia .
Pharm Dev Technol. 2014 Nov;19(7):799-805. doi: 10.3109/10837450.2013.829099. Epub 2013 Aug 22.
The present study was undertaken to evaluate the impact of various combinations of nonionic surfactants on self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in glibenclamide (GBN) nanoemulsion. Formulations (L1-L30) were prepared by spontaneous emulsification method. Prepared formulations were subjected to thermodynamic stability and self-nanoemulsification test. Results of thermodynamic stability and self-nanoemulsification tests were confirmed by further characterization of these formulations in terms of droplet size, viscosity, refractive index and % transmittance. Formulations prepared with Labrasol, HCO-60 and Gelucire-44/14 were found to be suitable for self-emulsifying drug delivery system only whereas those prepared with Tween-80 and Cremophor-EL were found to be suitable for self-nanoemulsifying or self-microemulsifying drug delivery system of GBN with respect to Lauroglycol-90 or Lauroglycol-FCC. Formulation L24 (Lauroglycol-FCC/Tween-80/ethanol/water) was optimized as best formulation for self-nanoemulsifying drug delivery system of GBN. These results indicated that Tween-80 could be the best surfactant in terms of self-nanoemulsification.
本研究旨在评估非离子表面活性剂的各种组合对两种等级的月桂二醇（月桂二醇-90和月桂二醇-FCC）在格列本脲（GBN）纳米乳中的自纳米乳化性能的影响。通过自发乳化法制备了配方（L1-L30）。对制备的配方进行了热力学稳定性和自纳米乳化测试。通过对这些配方的液滴尺寸、粘度、折射率和透光率进行进一步表征，证实了热力学稳定性和自纳米乳化测试的结果。发现用Labrasol、HCO-60和Gelucire-44/14制备的配方仅适用于自乳化给药系统，而用吐温-80和聚氧乙烯蓖麻油-EL制备的配方对于月桂二醇-90或月桂二醇-FCC而言，适用于GBN的自纳米乳化或自微乳化给药系统。配方L24（月桂二醇-FCC/吐温-80/乙醇/水）被优化为GBN自纳米乳化给药系统的最佳配方。这些结果表明，就自纳米乳化而言，吐温-80可能是最佳的表面活性剂。
